Physics-constrained dual-domain network reconstructs CBCT from two orthogonal X-rays in GYN radiotherapy

Retrospective: patient-specific physics-constrained network reconstructs 3D CBCT from 2 orthogonal X-rays (PSNR 48.02 dB, SSIM 0.988, MAE 24.89 HU) outperforming GAN & diffusion models in 15 GYN cancer patients. No external validation.

• Retrospective study using 360 CBCT scans from 15 GYN cancer patients, trained and tested patient-specifically.
• Qualitative improvement: reduced reconstruction artifacts and better anatomical consistency compared with baseline methods.
• Single-center, patient-specific model not validated across patients; lacks prospective clinical evaluation and external generalizability.

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