Brain connectome subtypes predict Alzheimer's progression independent of pathology burden

In mild cognitive impairment, brain connectome subtyping revealed a 'compromised' subgroup with extensive disruption and a 'preserved' subgroup. Despite similar Alzheimer's pathology burden, the compromised group showed faster cognitive decline and elevated progression risk (exa…

• Multi-center cohort study (sample size not reported) identified two MCI subtypes based on structural and functional connectome disruption.
• Transcriptomic analyses linked these connectome patterns to mitochondrial, synaptic, and neuroimmune processes.
• Limitation: No external validation reported; sample size and generalizability unclear.

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