IVIM Diffusion MRI Metrics Linked to Amyloid, Tau Burden, and Cognitive Decline in Aging

Retrospective machine learning analysis of IVIM diffusion MRI predicted amyloid status with 80% accuracy and correlated with amyloid (r=0.53), tau (r=0.61), and cognitive decline (r=-0.60) in 94 aging individuals (45 Aβ+).

• Study of 94 participants (45 Aβ+) who underwent simultaneous PET/MRI; ML model identified 25 IVIM features predictive of amyloid status with 80% accuracy on held-out data.
• Selected IVIM features correlated with tau burden (r=0.61, p<0.0001) and cognitive decline (r=-0.60, p<0.0001); the cognitive correlation persisted only in Aβ+ individuals (r=-0.61, p<0.0001).
• Single-center retrospective design without external validation; modest sample size limits generalizability.

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