Skeletal muscle density on coronary CTA predicts 10-year mortality and MI in SCOT-HEART trial

Deep-learning body composition analysis of coronary CTA in the SCOT-HEART trial showed lower skeletal muscle attenuation predicted all-cause mortality (HR 1.85, 95% CI 1.30–2.64) and MI (HR 1.58, 95% CI 1.07–2.33). The associations persisted after adjusting for coronary calcium…

• Retrospective analysis of 1,722 patients from the SCOT-HEART trial, median age ~58 years, 56% male.
• Greater lung attenuation, lower liver attenuation, and greater torso fat volume were associated with prevalent coronary artery disease.
• Myocardial volume and rib attenuation were associated with MI, but only skeletal muscle attenuation remained significant after adjusting for coronary calcium (HR 0.72, 95% CI 0.57–0.91).

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