Enlarged pallidum volume correlates with attention deficits and specific gene expression in schizophrenia

In a cross-sectional study of 137 participants, patients with schizophrenia showed slower attention task responses (p<0.05) and enlarged bilateral pallidum volume. Pallidum enlargement correlated with reduced alertness (r=0.42, p=4.3×10⁻⁴) and was linked to a distinct brain tran…

• Cross-sectional study of 65 schizophrenia patients and 72 controls with MRI and cognitive testing.
• Significant structural findings included enlarged bilateral pallidum, smaller right hippocampus, and reduced cortical thickness (all p<0.05).
• Limitations: cross-sectional design precludes causal inference; single-center cohort with moderate sample size may affect generalizability.

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