SVM model distinguishes central precocious puberty with AUC 0.83 in multicenter study

A support vector machine model using eight clinical and ultrasound predictors diagnosed central precocious puberty in girls with AUCs of 0.85 (internal) and 0.83 (external) in a retrospective multicenter study of 2,148 patients.

• Retrospective design across 4 Chinese centers; 2,148 girls with precocious puberty included.
• Key predictors: bone age minus chronological age, uterine volume, basal luteinizing hormone, among others.
• Retrospective; external validation still limited to Chinese children; prospective validation needed.

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