MELD Score Predicts Post-TIPS Liver Failure and Mortality in 25-Year Retrospective Study

A single-center study of 559 patients found a MELD score > 16 predicts post-TIPS liver failure, with an AUROC of 0.785 for predicting liver-insufficiency related death (grade 3 PTLF). The overall incidence of post-TIPS liver failure was 17%, with a 6% mortality rate.

• This retrospective, single-center study included 559 patients who underwent TIPS creation between 1998 and 2025.
• MELD score was a significant predictor, identifying a cutoff of 16 for increased risk of any grade post-TIPS liver failure.
• The primary limitation is the single-center, retrospective design over a long study period, which may limit external validity and introduce selection bias.

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