Federated foundation model for lifespan brain morphological connectome analysis

FedFound, a federated foundation model trained on 22,911 structural brain MRI connectomes (ages 0–100), demonstrated superior performance across 9 diagnostic tasks spanning neurodevelopmental, neuropsychiatric, and neurodegenerative disorders (exact metrics not reported).

• Design: Federated self-supervised pre-training on 22,911 lifespan connectomes, followed by supervised disease-specific refinement.
• Primary outcome: FedFound outperformed conventional approaches on 9 classification tasks, with qualitative interpretability shown.
• Limitation: No numerical performance metrics provided in the abstract; external validation on independent cohorts not yet documented.

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