Tea polyphenols and exercise metabolites may synergistically reinforce neurovascular stability via redox signaling pathways — a mechanistic model.

A translational synthesis proposes tea catechins (EGCG) and exercise-induced metabolites (lactate, BHB, SCFA) co-activate Nrf2/AMPK and suppress NF-κB to protect the blood-brain barrier. Proposed synergy reshapes gut microbiota toward SCFA production, potentially reducing neurov…

• This is a mechanistic review/proposal synthesizing preclinical and clinical evidence; no original interventional trial data or effect sizes are provided.
• The proposed model suggests combined tea polyphenols + exercise metabolites jointly regulate oxidative/inflammatory pathways, but a clinical dose-response relationship, optimal timing, and individual variation remain unknown.
• Incorporating this mechanistic framework into patient rehabilitation education is suggested, but the work does not report any patient-oriented outcomes.

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