LightGBM model predicts post-arthroplasty hypoproteinemia with external AUC 0.855

Multicenter retrospective: LightGBM model predicts post-TJA hypoproteinemia (external AUC 0.855). Age, erythrocyte sedimentation rate, surgery time, serum calcium, and anesthesia method were key predictors. Not yet prospectively validated.

• Multicenter retrospective study in 1,383 patients (training 585, internal validation 250, external validation 548).
• Model achieved training AUC 1.000, internal validation AUC 0.968, external validation AUC 0.855.
• Retrospective design; requires prospective validation before clinical use.

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