Meta-analysis: AI screening for osteoporosis on abdominal CT achieves pooled AUC of 0.931

AI algorithms applied to abdomen/lumbar-spine CT scans show excellent performance for opportunistic osteoporosis screening, with a pooled AUC of 0.931 (95% CI 0.926-0.936). Screening for spine fractures was also strong at AUC 0.863 (0.73-0.936). DXA served as the reference. Most…

• Systematic review and meta-analysis of 31 studies (26 for osteoporosis, 5 for fracture) using CT with DXA as reference.
• For abdomen/L-spine osteoporosis/non-osteoporosis screening, pooled sensitivity and specificity were not reported; heterogeneity was moderate (I²=47.24%).
• Majority of studies were retrospective and not externally validated; fracture screening analysis showed high heterogeneity (I²=64.8%).

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