Alpha-1 Antitrypsin Deficiency: Classic Imaging Patterns

Alpha-1 antitrypsin deficiency causes panlobular emphysema with lower-lobe predominance and often bronchiectasis. On CT, look for basal emphysema, sometimes with associated liver disease. Recognize this pattern to suggest genetic testing early.

• Educational blog post from LearningRadiology highlighting imaging findings of alpha-1 antitrypsin deficiency.
• Key CT features: lower-zone panlobular emphysema, bronchiectasis, and possible hepatic manifestations.
• Not a research study; serves as a board-review pearl for radiology trainees.

RadPigeon summaries are original and for information only. They are not clinical advice.