TACE-Induced Liver Injury: Review of Mechanisms, Prediction, and the Gut-Liver Axis

TACE-induced liver injury spans transient lab changes to post-TACE liver failure, but definitions vary widely, hampering study comparisons. Gut microbiota and NLRP3 inflammasome pathways may improve risk prediction.

• Narrative review of TACE-induced liver injury mechanisms, risk stratification, and prevention.
• Baseline hepatic reserve (Child-Pugh, ALBI) and tumor burden are key predictors; post-TACE ALBI deterioration tracks clinical trajectories.
• The literature suffers from heterogeneous definitions of post-TACE liver failure, limiting cross-study comparisons; emerging gut-liver axis and inflammasome data are early.

RadPigeon summaries are original and for information only. They are not clinical advice.