LearningRadiology Case Review: Langerhans Histiocytosis (Eosinophilic Granuloma)

LearningRadiology reviews the classic imaging features of Langerhans cell histiocytosis (eosinophilic granuloma), a focal form of LCH that typically presents as a solitary 'punched-out' lytic bone lesion without periosteal reaction in the skull or femur of a child, often mimicki…

• Educational review identifying the hallmark radiographic appearance of eosinophilic granuloma, a subtype of Langerhans cell histiocytosis.
• Classic presentation is a solitary, destructive 'punched-out' lytic lesion, frequently in the calvarium, mandible, ribs, or long bones of children and young adults.
• Teaching point emphasizes differentiating this benign-appearing lesion from Ewing sarcoma and osteomyelitis, and noting the potential for vertebra plana.

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