ICAD-LVO Stroke: Lower Reperfusion Success but Similar Functional Outcomes After EVT

In a meta-analysis of 11,326 patients, intracranial atherosclerotic disease (ICAD) LVO was associated with lower odds of successful reperfusion after endovascular treatment (OR 0.46, 95%CI 0.31–0.70), but functional independence and mortality did not differ from non-ICAD LVO. Sy…

• Systematic review and meta-analysis of 18 observational studies (3 prospective, 15 retrospective) in 11,326 adults with LVO stroke undergoing EVT.
• No significant differences for functional independence (OR 0.90, 95%CI 0.67–1.22) or mortality (OR 1.16, 95%CI 0.77–1.75); sICH risk was lower in ICAD (OR 0.72, 95%CI 0.54–0.96).
• Unadjusted pooled estimates from mostly retrospective studies; very-low certainty of evidence per GRADE.

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