CT Radiomics Predicts Liver Regeneration Biomarkers After Venous Embolization in a Porcine Model

Baseline CT radiomics predicted Ki-67 proliferation after liver venous embolization with AUC 0.84 (random forest) in a porcine proof-of-concept study. Combined portal + hepatic vein embolization drove stronger regenerative signaling than portal embolization alone in both healthy…

• Prospective porcine study (n=22; 11 healthy, 11 cirrhotic) comparing PVE, PVE+HVE, and sham; biomarkers (VEGF, Ki-67, angiopoietin-1, caspase 3) quantified by immunofluorescence at 4 weeks.
• PVE+HVE produced significantly greater angiogenesis than PVE alone in both healthy (P<0.01) and cirrhotic (P<0.001) livers; Ki-67 had the best radiomics discriminative performance (RF AUC 0.84, LR AUC 0.81) across 100 repeated 5-fold CV iterations.
• Key limitation: animal model only — results are not externally validated in humans, and sample size is small (n=22); clinical translation remains unproven.

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