CloudScope: Cloud-Connected Miniscope Enables Long-Term Multicontrast Brain Imaging in Live Animals

CloudScope, a cloud-based miniature microscope, enables >24-h autonomous multicontrast neuroimaging in freely moving animals — tracking neuronal activity, blood flow, oxygenation, and tumor microenvironments simultaneously (exact performance figures not reported in source).

• Preclinical tool; simultaneously captures neuronal activity, cerebral hemodynamics, oxygenation, and cellular dynamics ('neurosurveillance') — overcoming the <2-h limit of prior miniscopes.
• Deep learning applied to 24-h neuroimaging data predicted animal behavior; system also characterized seizure-induced neurovascular disruption and brain tumor microenvironments in vivo.
• Key limitation: purely preclinical/animal research — no human imaging data; translational relevance to clinical radiology is indirect and long-term.

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